Molecular characterization of the normal epithelial cell types that reside in the mammary gland is an important step toward understanding pathways that regulate...
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The epithelial cell signatures were used to interrogate mouse models of mammary tumorigenesis and to compare with their normal human counterpart subsets to identify conserved genes and networks.
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White symbols depict neighboring genes.
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We interrogated the expression profiles of whole mammary tumors isolated from these mouse models [ 14 ] for the expression signatures characteristic of our mouse MaSC-enriched, luminal progenitor, mature luminal, and stromal subpopulations. Evidence for a stem cell hierarchy in the adult human breast. For this analysis, we used a more comprehensive set of signature genes, by loosening slightly the FDR criteria, as described in Methods Tables S1-S3 in Additional files 4 , 5 , and 6.
M-A-T-T-I , 2 years ago. Here we performed genome-wide transcriptome analyses of three different mouse epithelial subpopulations and established pathways that are conserved in functionally equivalent subsets in humans by using specific gene signatures. Molecular definition of breast tumor heterogeneity. Comparison of the expression profiles of human and mouse subpopulations We previously reported the expression profiling of human mammary epithelial cell subpopulations, by using freshly sorted cells, unamplified material, and the Illumina platform [ 7 ].
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